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Question:

You have loaded a hazardous material into a cargo tank. What must you do before you move the vehicle?

A Close all manholes and valves. Be sure they are free of leaks.
Explaination

Before you start to drive a vehicle with a cargo tank containing hazardous materials, make sure that the manholes and valves are closed and leak-free. It is illegal to move a cargo tank containing any amount of hazardous materials for any distance if any valves or covers are open.