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To obtain a CDL, you must certify that

Certain medical conditions can affect your ability to drive commercial motor vehicles (CMVs) safely. Under federal regulation 49 CFR 391.41, you may be considered medically unqualified to operate CMVs if your health suffers from certain medical conditions such as addiction to drugs or alcohol, cardiovascular disease, epilepsy, insulin-dependent diabetes mellitus, psychiatric illness, and so on. However, an exception (medical variance) may be granted if you can show that your medical condition won't significantly affect your ability to operate CMVs. Contact the Federal Motor Carrier Safety Administration for details.