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To help you stay alert while driving, you should

The monotony and boredom of a long drive can lead to highway hypnosis and drowsiness. To prevent this, stop for a break about once every two hours or 100 miles. Some cold and allergy medications can cause drowsiness, sedation, or disturbed coordination, which makes them dangerous for CMV operators. If you are unsure about the effects of a particular medication, check the warning label or ask your pharmacist or doctor.