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To help you stay alert and safe while driving, you should

Unfortunately, some prescription and over-the-counter medications can cause drowsiness, sedation, or impaired coordination, which make them dangerous for CMV operators. If you are unsure about the effects of a particular medication, check the warning label or ask your pharmacist or doctor. Never try to fight drowsiness with coffee, fresh air, or especially alcohol. The only "cure" for being tired is sleeping until you are rested.