According to the state of California, you are considered involved in interstate commerce UNLESS the cargo you are transporting

A originates in the state and is headed for a location in the state.

Explaination

The only situation that does not qualify as interstate commerce is cargo originating in California and staying in the state.

B consists of waste or other hazardous substances.

C is headed for a location out of state.

D originates out of state.

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